Marks & Spencer has received planning permission to build its largest store for 10 years.
The 150,000 sq ft flagship store at Cheshire Oaks was approved by the communities and local government secretary John Denham last week.
Developer Simons is working on detailed designs for the £60 million project, which will start on site early next year, in preparation for opening in Spring 2012.
The store will include a number of sustainable features under the M&S Plan A scheme - a 100-point, five-year eco plan.
Simons development director Chris Newsome said: “This is a momentous day for Ellesmere Port, for M&S and for the region.
“We would like to thank everyone who has supported the scheme and look forward to working with Marks & Spencer to deliver this store for the Ellesmere Port community.”